If Respondus 4 is unable to publish a particular exam to your course, but other files publish fine, it generally indicates there is a problem with the original Respondus 4 file. In many cases, it is due to corrupted HTML that came across with a copy-and-paste from Word or a web page that might be removed with Respondus->File->"Clean Up HTML"
However, if there are still issues, submit a ticket to Respondus Support at: http://support.respondus.com with a copy of the Respondus 4 file and we'll take a look at it. Be sure to use the Respondus 4 Archive Wizard which is located on the Start menu.
If, however, the problem occurs with each exam you attempt to publish to the course, then the fault is with either the server settings entered into Respondus 4 or with the online course itself.